Starting Anti-COVID-19 Drug Discovery with Natural Products
DOI:
https://doi.org/10.21664/2238-8869.2021v10i1.p241-270Palabras clave:
artificial Intelligence, coronaviruses, drug discovery, HCoV infection, natural productsResumen
La COVID-19 se caracterizó como una pandemia debido a su rápida propagación y severidad en marzo de 2020. La familia Coronaviridae recibe su nombre de la organización de la glucoproteína 'espigas' ubicada en el sobre, en forma de corona cuando se observa al microscopio. . Los coronavirus sufren mutaciones frecuentes en su genoma debido a errores cometidos por la ARN polimerasa dependiente de ARN (RdRp, RDR). El SARS-CoV-2, el agente causal del COVID-19, es un virus altamente infeccioso y puede transmitirse de persona a persona. Se han informado actividades antivirales potentes de varios productos naturales, como alcaloides, chalcones, triterpenoides, pero sin eficacia ni seguridad clínicamente confirmadas, así como con los mecanismos subyacentes completos. Este artículo de revisión presenta los efectos antivirales de los productos naturales contra el SARS-CoV, HCoV-NL63, HCoV-229E y HCoV-OC43, mostrando que el licorino, emodina, promazina, saikosaponinas B2, silvestrol, la cefarantina, fangchinolina, tetrandrina, el ácido cafeico, el ácido clorogénico, el ácido gálico y la emetina son buenos candidatos para el tratamiento de las infecciones por coranavirus.
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2021-03-03
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SILVA, OSMAR NASCIMENTO et al. Starting Anti-COVID-19 Drug Discovery with Natural Products. Fronteira: Journal of Social, Technological and Environmental Science, [S. l.], v. 10, n. 1, p. 241–270, 2021. DOI: 10.21664/2238-8869.2021v10i1.p241-270. Disponível em: https://revistas2.unievangelica.edu.br/index.php/fronteiras/article/view/4719. Acesso em: 21 nov. 2024.
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