The PROTEOMIC TECHNOLOGY AS A STRATEGY APPLIED TO LABORATORY DIAGNOSIS

Abstract

Introduction: Proteomics is the study in charge of describing and quantifying proteins, as well as their interactions, population variations and changes in response to a pathological or physiological modification. Objective: To evaluate and describe the innovations promoted by proteomics in the laboratory context of pathological diagnosis, contributing to the advancement of the scientific development of clinical research. Methods: Quantification of publications available in the Pubmed database related to the term Proteomic from the year 2007 to October 2018 and analysis of the articles published in the year 2017 related to the descriptors proteômic and clinic diagnostic. Results: In the last 12 years, publications related to Proteomics have been growing steadily. In the 2017 publications where proteomics was related to clinical diagnosis, 48% of the applications were in biomarkers, 32.53% of the research objects were cancer, 74% of the tests performed were in vitro, 63.75% of the method was in identification of proteomic profile, 28.6% of the technique used was LC-MS-MS. Conclusion: Proteomics is a scientific area that has advanced and developed in recent years and can bring many contributions to the clinical diagnosis, but its application is still more focused on scientific research.