Chemoprotective Effect of Leaf Extracts of Cecropia distachya Huber (Urticaceae) in Mice Submitted to Oxidative Stress Induced by Cyclophosphamide
DOI:
https://doi.org/10.21664/2238-8869.2020v9i2.p103-127Palavras-chave:
Histologia, lesões oxidativas, hipoglicemia, imunossupressãoResumo
The objective of this work was to evaluate the chemoprotective effects of the embaúba Cecropia distachya Huber (two methanolic fractions: F1 and F2) on oxidative stress induced by cyclophosphamide (75 mg kg-1) in mice, as well as phytochemical analyzes by LC-MS/MS. In the experimental model, the fractions increased the hepatic and cardiac catalase (CAT), reduced glutathione (GSH) of the kidney and the heart. F1 increased platelet levels (PLT), hemogram (RBC), hematocrit (HCT) and hemoglobin (Hb) and F1 reduced hepatic lipid peroxidation (TBARS) and aspartate aminotransferase (AST) activity increased. F1 was attributed to possible hypoglycemic activity and possible immunosuppressive effects and F2 presented antimutagenic activity. In some cases, the fractions were also hepatotoxic. These results demonstrated that the fractions stimulate the antioxidant defenses, being hypoglycemic (F1) and antimutagenic (F2), and, the harmful effects attributed to the fractions may be the association of compounds that were not elucidated in this work.
Referências
Alves GAD, Souza RO, Rogez H, Masaki, H, Fonseca MJV 2016. Cecropia obtusa, an Amazonian ethanolic extract, exhibits photochemoprotective effect in vitro and balances the redox cellular state in response to UV radiation. Ind. Crops Prod. 94, 893–902.
Amien AI, Fahmy SR, Abd-Elgleel FM, Elaskalany SM 2015. Renoprotective effect of Mangifera indica polysaccharides and silymarin against cyclophosphamide toxicity in rats. J. Basic. Appl. Zool. 72, 154–162.
Andrade-Cetto A, Wiedenfeld AH 2001. Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. J. Ethnopharmacol. 78, 145–149.
Aragão, D.M., Guarize, L., Lanini, J., Costa, J.C., Garcia, R.M.G., Scio, E., 2010. Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats. J. Ethnopharmacol. 128, 629–633.
Arend DP, Santos TC, Sonaglio D, Santos ALG, Reginatto FH, Campos AM 2011. Experimental design as a tool to evaluate chlorogenic and caffeic acids extracted from Cecropia glaziovii Sneth. J. Pharm. Biomed. Anal. 54, 58–66.
Arend DP, Santos TC, Cazarolli LH, Hort MA, Sonaglioa D, Santos ALG, Ribeiro-do-Valle RM, Silva FR, Campos AM 2015. In vivo potential hypoglycemic and in vitro vasorelaxant effects of Cecropia glaziovii standardized extracts. Rev. Bras. Farmacogn. 25, 473–484.
Basu A, Bhattacharjee A, Samanta, A, Bhattacharya S 2015. Prevention of cyclophosphamide-induced hepatotoxicity and genotoxicity: Effect of an cysteine based oxovanadium (IV) complex on oxidative stress and DNA damage. Environ. Toxicol. Pharmacol. 40, 747–757.
Bhatt L, Sebastian B, Joshi V 2017. Mangiferin protects rat myocardial tissue against cyclophosphamide induced cardiotoxicity. J. Ayurveda Integr. Med. 8, 62–67.
Bhattacharjee A, Basu A, Biswas J, Bhattacharya S 2015. Nano-Se attenuates cyclophosphamide-induced pulmonary injury through modulation of oxidative stress and DNA damage in Swiss albino mice. Mol. Cell Biochem. 405, 243-256.
Bradford MM 1976. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248–254.
Brahim SB, Kelebek H, Ammar S, Abichou M, Bouaziz M 2017. LC–MS phenolic profiling combined with multivariate analysis as an approach for the characterization of extra virgin olive oils of four rare Tunisian cultivars during ripening. Food Chem. 229, 9–19.
Brandão MGL, Souza PJ, Grael CFF, Scalon V, Santos ACP, Salimenha MF, Monte-Mor, RLM, Biodiversidade, uso tradicional de plantas medicinais e produção de fitoterápico sem Minas Gerais. [cited 2017 Jan 15]. Available from: http://www.cedeplar.ufmg.br/seminarios/seminario_diamantina/2010/D10A022.pdf, 2010
Buege JA, Aust, SD 1978. Microsomal lipid peroxidation. Methods in enzymology. 52, 302–309.
Ceribasi AO, Türk G, Sönmez M, Sakin F, Atessahim A 2010. Toxic effect of cyclophosphamide on sperm morphology, testicular histology and blood oxidant-antioxidant balance, and protective roles of lycopene and ellagic acid. Basic Clin. Pharmacol. Toxicol. 107, 730–736.
Chakraborty P, Kumar S, Dutta D, Gupta V 2009. Role of antioxidants in common health diseases. Res. J. Pharm. Technol. 2, 238–244.
Duan K, Yuan Z, Guo W, Meng Y, Cui Y, Kong D, Zhang L 2011. LC-MS/MS determination and pharmacokinetic study of five flavone components after solvent extraction/acid hydrolysis in rat plasma after oral administration of Verbena officinalis L. extract. J. Ethnopharmacol. 135, 201–208.
Falzon CC, Balabanova A 2017. Phytotherapy An Introduction to Herbal Medicine. Prim. Care 44, 217–227.
Firmo WC, Menezes VJ, Passos CE, Dias CN, Neto MS, Olea RS 2011. Contexto histórico, uso popular e concepção científica sobre plantas medicinais. [cited 2017 jul 20]. Available from:http://www.periodicoseletronicos.ufma.br/index.php/cadernosdepesquisa/article/view/746/2578.
Ganeshpurkar A, Saluja AK 2017. The pharmacological potential of rutin. Saudi Pharm. J. 25, 149–164.
Gazal M, Ortmann CF, Martins FA, Streck EL, Quevedo J, Campos AM, Stefanello FM, Kaster, MPD, Ghisleni G, Reginatto FH, Lencina CL 2014. Antidepressant-like effects of aqueous extract from Cecropia pachystachya leaves in a mouse model of chronic unpredictable stress. Brain Res. Bull. 108, 10–17.
George VC, Dellaire G, Rupasinghea V 2017. Plant flavonoids in cancer chemoprevention: role in genome stability. J. Nutr. Biochem. 45, 1–14.
Ghosh P, Bhattacharjee A, Basu A, Singha S, Bhattacharya S 2015. Attenuation of cyclophosphamide-induced pulmonary toxicity in Swiss albino mice by naphthalimide-based organoselenium compound 2-(5-selenocyanatopentyl) - benzo[de]isoquinoline 1,3-dione. Pharm. Biol. 53, 524–532.
Golan ED, Tashjian HA Armstrong, JE, Armstrong WA 2014. Princípios de farmacologia: a base fisiopatológica da farmacoterapia, third ed. Guanabara Koogan, Rio de Janeiro.
Green K, Brand MD, Murphy MP 2004. Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes 53, 110–118.
Gupta A, Gautam MK, Singh R, Kumar MV, Rao CV, Goel RK, Anupurba S 2001. Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. J. Ethnopharmacol. 78, 145–149.
Habig WH, Michael JP, Jakoby WB 1974. Glutathione-S-transferases: the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 25, 7130–7139.
Han X, Xue X, Zhao Y, Li Y, Liu W, Zhang J, Fan S 2017. Rutin-enriched extract from Coriandrum sativum L. ameliorates ionizing radiation-induced hematopoietic injury. Int. J. Mol. Sci. 18–942.
Hang JH 2013. Modification and inactivation of Cu,Zn-superoxide dismutase by the lipid peroxidation product, acrolein. BMB Rep. 46, 555-560.
Iriti M, Kubina R, Cochis A, Sorrentino R, Varoni EM, Kabała-Dzik A, Azzimonti B, Dziedzic A, Rimondini L, Wojtyczka RD 2017. Rutin, a quercetin glycoside, restores chemosensitivity in human breast cancer cells. Phytother. Res. 31, 1529-1538.
Jnaneshwari S, Hemshekhar M, Santhosh MS, Sunitha K, Thushara R, Thirunavukkarasu C, Kemparaju K, Girish KS 2013. Crocin, a dietary colorant mitigates cyclophosphamide-induced organ toxicity by modulating antioxidant status and inflammatory cytokines. J. Pharm. Pharmacol, 65, 604–614.
Khan JA, Shahdad S, Makhdoomi MA, Hamid S, Bhat GM, Jan Y, Nazir S, Bashir Z, Banoo S 2014. Effect of cyclophosphamide on the microanatomy of liver of albino rats. Int. J. Res. Med. Sci. 2, 1466–1469.
Kufe DW, Pollock RD, Weichselbaum RR, Bast RC, Gansler TS, Holland JF, Frei E, Holland-Frei 2003. Cancer Medicine, sixth edition, New York.
Lorenzi H, Matos FJA 2008. Plantas medicinais no Brasil: nativas e exóticas, second ed. Nova Odessa.
Lin S, Hao G, Longa M, Laia F, Lia Q, Xionga Y, Tiana Y, Laia D 2017. Oyster (Ostrea plicatula Gmelin) polysaccharides intervention ameliorates cyclophosphamide—Induced genotoxicity and hepatotoxicity in mice via the Nrf2—ARE pathway. Biomed. Pharmacother. 95, 1067–1071.
MacGregor JT, Heddle JA, Hite M, Margolin BH, Ramel C, Salamone MF, Tice RR, Wild D 1987. Guidelines for the conduct of micronucleus assays in mammalian bone marrow erythrocytes. Mutat. Res. 189, 103–112.
Maquiaveli CC, Silva ER, Rosa LC, Francescato HD, Lucon JF, Silva CG, Casarini DE, Ronchi FA, Coimbra TM 2014. Cecropia pachytachya extract attenuated the renal lesion in 5/6 neprectomized rats by reducing inflammation and renal arginase activity. J. Ethnopharmacol. 158, 49–57.
Manoharan K, Banerjee MR 1985. β-Carotene reduces sister chromatid exchange induce chemical carcinogens in mouse mammary cells in organ culture. Cell Biol. Int. Rep. 9, 783–789.
Marshall WJ, Lapley M, Day AP, Ayling RM 2016. Bioquímica Clínica, third edition, São Paulo.
Mendonça ED, Silva, Santos JMS, Carvalho P, Papke DKM, Ortmann CF, Picada JN, Reginatto FH, Ferraz, ABF 2016. Genotoxic, mutagenic and antigenotoxic effects of Cecropia pachystachya Trécul aqueous extract using in vivo and in vitro assays. J. Ethnopharmacol. 193, 214–220.
Misra HP, Fridovich I 1972. The role of superoxide anion in the auto-oxidation o epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 247, 3170–3175.
Moghe A, Ghare S, Lamoreau B, Mohammad M, Barve S, McClain, C., Joshi-Barve S 2015. Molecular mechanisms of acrolein toxicity: relevance to human disease. Toxicol. Sci., 143, 242–255.
Müller SD, Florentino D, Ortmann CF, Martins FA, Danielski LG, Michels M, Constantino, LS, Petronilho F, Reginatto, FH 2016. Anti-inflammatory and antioxidant activities of aqueous extract of Cecropia glaziovii leaves. J. Ethnopharmacol. 185, 255–262.
Nafees S, Rashid S, Ali N, Hasan SK, Sultana S 2015. Rutin ameliorates cyclophosphamide induced oxidative stress and inflammation in Wistar rats: Role of NFjB/MAPK pathway. Chem. Biol. Interact. 231, 98–107.
Nayak BS 2006. Cecropia peltata L. (Cecropiaceae) has wound-healing potential: a preclinical study in a Sprague Dawley rat model. Int. J. Low Extrem. Wounds 5, 20–26.
Nelson DP, Kiesow LA 1972. Enthalphy of decomposition of hydrogen peroxide by catalase at 25 °C (with molar extinction coefficients of H2O2 solution in the UV). Anal. Biochem. 49, 474–478.
Oboh G, Olabiyi AA, Akinyemi AJ 2013. Inhibitory effect of aqueous extract of different parts of unripe pawpaw (Carica papaya) fruit on Fe2+ induced oxidative stress in rat pancreas in vitro. Pharm. Biol. 51, 1165–1174.
Ortmann CF, Réus GZ, Ignácio ZM, Abelaira HM, Titus SE, Carvalho P, Arent CO, Santos MA, Matias BI, Martins MM, Campos AM, Petronilho F, Teixeira LJ, Morais MO, Streck EL, Quevedo J, Reginatto FH 2016. Enriched flavonoid fraction from Cecropia pachystachya trécul leaves exerts antidepressant-like behavior and protects brain against oxidative stress in rats subjected to chronic mild stress. Neurotox. Res. 29, 469–83.
Peláez, G.L., Sierra, J.A., Alzated, F., Holzgrabee, U., Ramirez-Pineda, J.R., 2013. Pentacyclic triterpenes from Cecropia telenitida with immunomodulatory activity on dendritic cells. Rev. Bras. Farmacogn. 23, 754-761.
Pereira BCA 1991. Teste estatístico para comparar proporções em problemas de citogenética. In: Rabello-Gay MN, Rodrigues MAR, Monteleone Neto R, organizadores. Mutagênese, carcinogênese e teratogênese: métodos e critérios de avaliação. Soc. Bras. Gene. 113–121.
Petrinilho F, Dal-Pizzol F, Costa GM, Kappel VD, Oliveira SQ, Fortunato J, Cittadini-Zanette V, Moreira JCF, Simões CMO, Dal-Pizzol F, Reginatto FH 2012. Hepatoprotective effects and HSV-1 activity of the hydroethanolic extract of Cecropia glaziovii (embaúba-vermelha) against acyclovir-resistant strain. Pharm. Biol. 50, 911–918.
Quintela JCS 2013. Cecropia catarinensis Cuatrecasas (Urticaceae): Chemical and biological studies. Universidade do Porto.
Revilla-Monsalve MC, Andrade-Cetto A, Palomino Garibay MA, Wiedenfeld H, Islas-Andrade S 2007. Hypoglycemic effect of Cecropia obtusifolia Bertol aqueous extracts on type 2 diabetic patients. J. Ethnopharmacol. 111, 636–40.
Ribeiro LR, Salvadori DM, Marques EK 2003. Mutagênse ambiental. Editora Ulbra, Canoas.
Roy SS, Chakraborty P, Bhattacharya S 2014. Intervention in cyclophosphamide induced oxidative stress and DNA damage by a flavonyl-thiazolidinedione based organoselenocyanate and evaluation of its efficacy during adjuvant therapy in tumor bearing mice. Eur. J. Med. Chem. 73, 195–209.
Sá PGS, Guimarães AL, Oliveira AP, Siqueira Filho JA, Fontana AP, Damasceno PKF, Branco CRC, Branco A, Almeida JRG 2012. Fenóis totais, flavonoides totais e atividade antioxidante de Selaginella convoluta (Arn.) spring (Selaginellaceae). Rev. de Cienc. Farmac. 33, 561–566.
Sedlack J, Lindsay RH 1978. Estimation of total, protein bound, and nonprotein sulphydryl groups in tissue with ellman’s reagent. Anal. Biochem. 25, 192–205.
Shanmugarajan TS, Arunsundar M, Somasundaram I, Krishnakumar E, Sivaraman D, Ravichandiran V 2008. Cardioprotective effect of Ficus hispida Linn. on cyclophosphamide provoked oxidative myocardial injury in a rat model. Int. J. Pharmacol. 4, 78–87.
Silva J, Herrmann SN, Heuser V, Peres W, Marroni NP, González-Gallego J, Erdtmann B 2002. Evaluation of the genotoxic effect of rutin and quercetin by comet assay and micronucleus test. Food Chem. Toxicol. 40, 941–947.
Song Y, Zhang C, Wang C, Zhao L, Wang Z, Dai Z, Lin S, Kang H, Xiaobin M 2016. Ferulic acid against cyclophosphamide-induced heart toxicity in mice by inhibiting nf-kb pathway. Evid. Based Complement. Alternat. Med. ID 1261270, 8.
Sousa CMM, Silva HR, Vieira JR, GM, Ayres MCC, Costa CLS, Araújo DS, Cavalcenti, LCD, Barros EDS, Araújo PBM, Brandão MS, Chaves M.H 2007. Fenóis totais e atividade antioxidante de cinco plantas medicinais. Quim. Nova 30, 351–355.
Sousa SA, Alves MA, Silva SCS, Nogueira JRS, Martins DHN, Fonseca-Bazzo YM, Galdos-Riveros AC 2015. Phytochemical screening assessment, antioxidant capacity and antimicrobial susceptibility of extracts from Cecropia pachystachya Trécul. Cecropiaceae (Urticaceae) as source for herbal medicines development. Int. J. Pharmacogn. 12, 570-576.
Souza MP, Bataglion GA, Silva FM, Almeida RA, Paz WH, Nobre TA, Marinho JV, Salvador MJ, Fidelis CH, Acho LD, Souza AD, Nunomura RC, Eberlin MN, Lima ES, Koolen HH 2016. Phenolic and aroma compositions of pitomba fruit (Talisia esculenta Radlk.) assessed by LC–MS/MS and HS-SPME/GC–MS. Food Res. Int. 83, 87–94.
Teixeira LN, Lima MA, Silva MJM, Carvalho LFM 2013. Screening fitoquímico e avaliação do potencial de captura do radical DPPH pelos extratos de Manilkara sapota L. [cited 2017 nov 29].
Available from: file:///C:/Users/User/Downloads/testes%20radical%20DDPH%20(1).pdf
Toledo VM, Tellez MGO, Sortibràn ANC, Andrade-Cetto A. Rodriguez-Arnaiz R 2008. Genotoxicity testing of Cecropia obtusifolia extracts in two in vivo assays: The wing somatic mutation and recombination test of drosophila and the human cytokinesis-block micronucleus test. J. Ethnopharmacol. 116, 58–63.
Üngeder Ü, Aydın SA, Basaran AA, Basaran N 2004. The modulating effects of quercetin and rutin on the mitomycin C induced DNA damage. Toxicol. Lett. 151, 143–149.
Wang TY, Lia Q, Bia KS 2018. Bioactive flavonoids in medicinal plants: Structure, Activity and Biological fate. Asian J. Pharm. Sci. 13, 12–23.
Waters MD, Brady AL, Stack HF, Broxkman HE 1990. Antimutagenic profiles for some model compounds. Mutat. Res. 238, 57–85.
Yousefipour Z, Ranganna K, Newaz MA, Milton SG 2005. Mechanism of acrolein-induced vascular toxicity. J. Physiol. Pharmacol. 56, 337–353.
Yu Q, Nie SP, Wang JQ, Liu XZ, Yin PF, Huang DF, Li WJ, Gong DM, Xie MY 2014. Chemoprotective effects of Ganoderma atrum polysaccharide in cyclophosphamide-induced mice. Int. J. Biol. Macromol. 64, 395–401.
Zang Y, Igarashi K, Li Y 2016. Anti-diabetic effects of luteolin and luteolin-7-O-glucoside on KK-Ay mice. Biosci. Biotechnol. Biochem. 80, 1580-1586.
Zhang L, Gong AG, Riaz K, Deng JY, Ho CM, Lin HQ, Dong TT, Lee YK, Tsim KW 2017. A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide-induced anemic rats. FEBS Open Bio 7, 318–323.
Zhou J, Qi Y, Ritho J, Zhang Y, Zheng X, Wu L, Li Y, Sun L 2016. Flavonoid glycosides as floral origin markers to discriminate of unifloral bee pollen by LC-MS/MS. J. Ethnopharmacol. 181, 20–25.
Amien AI, Fahmy SR, Abd-Elgleel FM, Elaskalany SM 2015. Renoprotective effect of Mangifera indica polysaccharides and silymarin against cyclophosphamide toxicity in rats. J. Basic. Appl. Zool. 72, 154–162.
Andrade-Cetto A, Wiedenfeld AH 2001. Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. J. Ethnopharmacol. 78, 145–149.
Aragão, D.M., Guarize, L., Lanini, J., Costa, J.C., Garcia, R.M.G., Scio, E., 2010. Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats. J. Ethnopharmacol. 128, 629–633.
Arend DP, Santos TC, Sonaglio D, Santos ALG, Reginatto FH, Campos AM 2011. Experimental design as a tool to evaluate chlorogenic and caffeic acids extracted from Cecropia glaziovii Sneth. J. Pharm. Biomed. Anal. 54, 58–66.
Arend DP, Santos TC, Cazarolli LH, Hort MA, Sonaglioa D, Santos ALG, Ribeiro-do-Valle RM, Silva FR, Campos AM 2015. In vivo potential hypoglycemic and in vitro vasorelaxant effects of Cecropia glaziovii standardized extracts. Rev. Bras. Farmacogn. 25, 473–484.
Basu A, Bhattacharjee A, Samanta, A, Bhattacharya S 2015. Prevention of cyclophosphamide-induced hepatotoxicity and genotoxicity: Effect of an cysteine based oxovanadium (IV) complex on oxidative stress and DNA damage. Environ. Toxicol. Pharmacol. 40, 747–757.
Bhatt L, Sebastian B, Joshi V 2017. Mangiferin protects rat myocardial tissue against cyclophosphamide induced cardiotoxicity. J. Ayurveda Integr. Med. 8, 62–67.
Bhattacharjee A, Basu A, Biswas J, Bhattacharya S 2015. Nano-Se attenuates cyclophosphamide-induced pulmonary injury through modulation of oxidative stress and DNA damage in Swiss albino mice. Mol. Cell Biochem. 405, 243-256.
Bradford MM 1976. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248–254.
Brahim SB, Kelebek H, Ammar S, Abichou M, Bouaziz M 2017. LC–MS phenolic profiling combined with multivariate analysis as an approach for the characterization of extra virgin olive oils of four rare Tunisian cultivars during ripening. Food Chem. 229, 9–19.
Brandão MGL, Souza PJ, Grael CFF, Scalon V, Santos ACP, Salimenha MF, Monte-Mor, RLM, Biodiversidade, uso tradicional de plantas medicinais e produção de fitoterápico sem Minas Gerais. [cited 2017 Jan 15]. Available from: http://www.cedeplar.ufmg.br/seminarios/seminario_diamantina/2010/D10A022.pdf, 2010
Buege JA, Aust, SD 1978. Microsomal lipid peroxidation. Methods in enzymology. 52, 302–309.
Ceribasi AO, Türk G, Sönmez M, Sakin F, Atessahim A 2010. Toxic effect of cyclophosphamide on sperm morphology, testicular histology and blood oxidant-antioxidant balance, and protective roles of lycopene and ellagic acid. Basic Clin. Pharmacol. Toxicol. 107, 730–736.
Chakraborty P, Kumar S, Dutta D, Gupta V 2009. Role of antioxidants in common health diseases. Res. J. Pharm. Technol. 2, 238–244.
Duan K, Yuan Z, Guo W, Meng Y, Cui Y, Kong D, Zhang L 2011. LC-MS/MS determination and pharmacokinetic study of five flavone components after solvent extraction/acid hydrolysis in rat plasma after oral administration of Verbena officinalis L. extract. J. Ethnopharmacol. 135, 201–208.
Falzon CC, Balabanova A 2017. Phytotherapy An Introduction to Herbal Medicine. Prim. Care 44, 217–227.
Firmo WC, Menezes VJ, Passos CE, Dias CN, Neto MS, Olea RS 2011. Contexto histórico, uso popular e concepção científica sobre plantas medicinais. [cited 2017 jul 20]. Available from:http://www.periodicoseletronicos.ufma.br/index.php/cadernosdepesquisa/article/view/746/2578.
Ganeshpurkar A, Saluja AK 2017. The pharmacological potential of rutin. Saudi Pharm. J. 25, 149–164.
Gazal M, Ortmann CF, Martins FA, Streck EL, Quevedo J, Campos AM, Stefanello FM, Kaster, MPD, Ghisleni G, Reginatto FH, Lencina CL 2014. Antidepressant-like effects of aqueous extract from Cecropia pachystachya leaves in a mouse model of chronic unpredictable stress. Brain Res. Bull. 108, 10–17.
George VC, Dellaire G, Rupasinghea V 2017. Plant flavonoids in cancer chemoprevention: role in genome stability. J. Nutr. Biochem. 45, 1–14.
Ghosh P, Bhattacharjee A, Basu A, Singha S, Bhattacharya S 2015. Attenuation of cyclophosphamide-induced pulmonary toxicity in Swiss albino mice by naphthalimide-based organoselenium compound 2-(5-selenocyanatopentyl) - benzo[de]isoquinoline 1,3-dione. Pharm. Biol. 53, 524–532.
Golan ED, Tashjian HA Armstrong, JE, Armstrong WA 2014. Princípios de farmacologia: a base fisiopatológica da farmacoterapia, third ed. Guanabara Koogan, Rio de Janeiro.
Green K, Brand MD, Murphy MP 2004. Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes 53, 110–118.
Gupta A, Gautam MK, Singh R, Kumar MV, Rao CV, Goel RK, Anupurba S 2001. Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. J. Ethnopharmacol. 78, 145–149.
Habig WH, Michael JP, Jakoby WB 1974. Glutathione-S-transferases: the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 25, 7130–7139.
Han X, Xue X, Zhao Y, Li Y, Liu W, Zhang J, Fan S 2017. Rutin-enriched extract from Coriandrum sativum L. ameliorates ionizing radiation-induced hematopoietic injury. Int. J. Mol. Sci. 18–942.
Hang JH 2013. Modification and inactivation of Cu,Zn-superoxide dismutase by the lipid peroxidation product, acrolein. BMB Rep. 46, 555-560.
Iriti M, Kubina R, Cochis A, Sorrentino R, Varoni EM, Kabała-Dzik A, Azzimonti B, Dziedzic A, Rimondini L, Wojtyczka RD 2017. Rutin, a quercetin glycoside, restores chemosensitivity in human breast cancer cells. Phytother. Res. 31, 1529-1538.
Jnaneshwari S, Hemshekhar M, Santhosh MS, Sunitha K, Thushara R, Thirunavukkarasu C, Kemparaju K, Girish KS 2013. Crocin, a dietary colorant mitigates cyclophosphamide-induced organ toxicity by modulating antioxidant status and inflammatory cytokines. J. Pharm. Pharmacol, 65, 604–614.
Khan JA, Shahdad S, Makhdoomi MA, Hamid S, Bhat GM, Jan Y, Nazir S, Bashir Z, Banoo S 2014. Effect of cyclophosphamide on the microanatomy of liver of albino rats. Int. J. Res. Med. Sci. 2, 1466–1469.
Kufe DW, Pollock RD, Weichselbaum RR, Bast RC, Gansler TS, Holland JF, Frei E, Holland-Frei 2003. Cancer Medicine, sixth edition, New York.
Lorenzi H, Matos FJA 2008. Plantas medicinais no Brasil: nativas e exóticas, second ed. Nova Odessa.
Lin S, Hao G, Longa M, Laia F, Lia Q, Xionga Y, Tiana Y, Laia D 2017. Oyster (Ostrea plicatula Gmelin) polysaccharides intervention ameliorates cyclophosphamide—Induced genotoxicity and hepatotoxicity in mice via the Nrf2—ARE pathway. Biomed. Pharmacother. 95, 1067–1071.
MacGregor JT, Heddle JA, Hite M, Margolin BH, Ramel C, Salamone MF, Tice RR, Wild D 1987. Guidelines for the conduct of micronucleus assays in mammalian bone marrow erythrocytes. Mutat. Res. 189, 103–112.
Maquiaveli CC, Silva ER, Rosa LC, Francescato HD, Lucon JF, Silva CG, Casarini DE, Ronchi FA, Coimbra TM 2014. Cecropia pachytachya extract attenuated the renal lesion in 5/6 neprectomized rats by reducing inflammation and renal arginase activity. J. Ethnopharmacol. 158, 49–57.
Manoharan K, Banerjee MR 1985. β-Carotene reduces sister chromatid exchange induce chemical carcinogens in mouse mammary cells in organ culture. Cell Biol. Int. Rep. 9, 783–789.
Marshall WJ, Lapley M, Day AP, Ayling RM 2016. Bioquímica Clínica, third edition, São Paulo.
Mendonça ED, Silva, Santos JMS, Carvalho P, Papke DKM, Ortmann CF, Picada JN, Reginatto FH, Ferraz, ABF 2016. Genotoxic, mutagenic and antigenotoxic effects of Cecropia pachystachya Trécul aqueous extract using in vivo and in vitro assays. J. Ethnopharmacol. 193, 214–220.
Misra HP, Fridovich I 1972. The role of superoxide anion in the auto-oxidation o epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 247, 3170–3175.
Moghe A, Ghare S, Lamoreau B, Mohammad M, Barve S, McClain, C., Joshi-Barve S 2015. Molecular mechanisms of acrolein toxicity: relevance to human disease. Toxicol. Sci., 143, 242–255.
Müller SD, Florentino D, Ortmann CF, Martins FA, Danielski LG, Michels M, Constantino, LS, Petronilho F, Reginatto, FH 2016. Anti-inflammatory and antioxidant activities of aqueous extract of Cecropia glaziovii leaves. J. Ethnopharmacol. 185, 255–262.
Nafees S, Rashid S, Ali N, Hasan SK, Sultana S 2015. Rutin ameliorates cyclophosphamide induced oxidative stress and inflammation in Wistar rats: Role of NFjB/MAPK pathway. Chem. Biol. Interact. 231, 98–107.
Nayak BS 2006. Cecropia peltata L. (Cecropiaceae) has wound-healing potential: a preclinical study in a Sprague Dawley rat model. Int. J. Low Extrem. Wounds 5, 20–26.
Nelson DP, Kiesow LA 1972. Enthalphy of decomposition of hydrogen peroxide by catalase at 25 °C (with molar extinction coefficients of H2O2 solution in the UV). Anal. Biochem. 49, 474–478.
Oboh G, Olabiyi AA, Akinyemi AJ 2013. Inhibitory effect of aqueous extract of different parts of unripe pawpaw (Carica papaya) fruit on Fe2+ induced oxidative stress in rat pancreas in vitro. Pharm. Biol. 51, 1165–1174.
Ortmann CF, Réus GZ, Ignácio ZM, Abelaira HM, Titus SE, Carvalho P, Arent CO, Santos MA, Matias BI, Martins MM, Campos AM, Petronilho F, Teixeira LJ, Morais MO, Streck EL, Quevedo J, Reginatto FH 2016. Enriched flavonoid fraction from Cecropia pachystachya trécul leaves exerts antidepressant-like behavior and protects brain against oxidative stress in rats subjected to chronic mild stress. Neurotox. Res. 29, 469–83.
Peláez, G.L., Sierra, J.A., Alzated, F., Holzgrabee, U., Ramirez-Pineda, J.R., 2013. Pentacyclic triterpenes from Cecropia telenitida with immunomodulatory activity on dendritic cells. Rev. Bras. Farmacogn. 23, 754-761.
Pereira BCA 1991. Teste estatístico para comparar proporções em problemas de citogenética. In: Rabello-Gay MN, Rodrigues MAR, Monteleone Neto R, organizadores. Mutagênese, carcinogênese e teratogênese: métodos e critérios de avaliação. Soc. Bras. Gene. 113–121.
Petrinilho F, Dal-Pizzol F, Costa GM, Kappel VD, Oliveira SQ, Fortunato J, Cittadini-Zanette V, Moreira JCF, Simões CMO, Dal-Pizzol F, Reginatto FH 2012. Hepatoprotective effects and HSV-1 activity of the hydroethanolic extract of Cecropia glaziovii (embaúba-vermelha) against acyclovir-resistant strain. Pharm. Biol. 50, 911–918.
Quintela JCS 2013. Cecropia catarinensis Cuatrecasas (Urticaceae): Chemical and biological studies. Universidade do Porto.
Revilla-Monsalve MC, Andrade-Cetto A, Palomino Garibay MA, Wiedenfeld H, Islas-Andrade S 2007. Hypoglycemic effect of Cecropia obtusifolia Bertol aqueous extracts on type 2 diabetic patients. J. Ethnopharmacol. 111, 636–40.
Ribeiro LR, Salvadori DM, Marques EK 2003. Mutagênse ambiental. Editora Ulbra, Canoas.
Roy SS, Chakraborty P, Bhattacharya S 2014. Intervention in cyclophosphamide induced oxidative stress and DNA damage by a flavonyl-thiazolidinedione based organoselenocyanate and evaluation of its efficacy during adjuvant therapy in tumor bearing mice. Eur. J. Med. Chem. 73, 195–209.
Sá PGS, Guimarães AL, Oliveira AP, Siqueira Filho JA, Fontana AP, Damasceno PKF, Branco CRC, Branco A, Almeida JRG 2012. Fenóis totais, flavonoides totais e atividade antioxidante de Selaginella convoluta (Arn.) spring (Selaginellaceae). Rev. de Cienc. Farmac. 33, 561–566.
Sedlack J, Lindsay RH 1978. Estimation of total, protein bound, and nonprotein sulphydryl groups in tissue with ellman’s reagent. Anal. Biochem. 25, 192–205.
Shanmugarajan TS, Arunsundar M, Somasundaram I, Krishnakumar E, Sivaraman D, Ravichandiran V 2008. Cardioprotective effect of Ficus hispida Linn. on cyclophosphamide provoked oxidative myocardial injury in a rat model. Int. J. Pharmacol. 4, 78–87.
Silva J, Herrmann SN, Heuser V, Peres W, Marroni NP, González-Gallego J, Erdtmann B 2002. Evaluation of the genotoxic effect of rutin and quercetin by comet assay and micronucleus test. Food Chem. Toxicol. 40, 941–947.
Song Y, Zhang C, Wang C, Zhao L, Wang Z, Dai Z, Lin S, Kang H, Xiaobin M 2016. Ferulic acid against cyclophosphamide-induced heart toxicity in mice by inhibiting nf-kb pathway. Evid. Based Complement. Alternat. Med. ID 1261270, 8.
Sousa CMM, Silva HR, Vieira JR, GM, Ayres MCC, Costa CLS, Araújo DS, Cavalcenti, LCD, Barros EDS, Araújo PBM, Brandão MS, Chaves M.H 2007. Fenóis totais e atividade antioxidante de cinco plantas medicinais. Quim. Nova 30, 351–355.
Sousa SA, Alves MA, Silva SCS, Nogueira JRS, Martins DHN, Fonseca-Bazzo YM, Galdos-Riveros AC 2015. Phytochemical screening assessment, antioxidant capacity and antimicrobial susceptibility of extracts from Cecropia pachystachya Trécul. Cecropiaceae (Urticaceae) as source for herbal medicines development. Int. J. Pharmacogn. 12, 570-576.
Souza MP, Bataglion GA, Silva FM, Almeida RA, Paz WH, Nobre TA, Marinho JV, Salvador MJ, Fidelis CH, Acho LD, Souza AD, Nunomura RC, Eberlin MN, Lima ES, Koolen HH 2016. Phenolic and aroma compositions of pitomba fruit (Talisia esculenta Radlk.) assessed by LC–MS/MS and HS-SPME/GC–MS. Food Res. Int. 83, 87–94.
Teixeira LN, Lima MA, Silva MJM, Carvalho LFM 2013. Screening fitoquímico e avaliação do potencial de captura do radical DPPH pelos extratos de Manilkara sapota L. [cited 2017 nov 29].
Available from: file:///C:/Users/User/Downloads/testes%20radical%20DDPH%20(1).pdf
Toledo VM, Tellez MGO, Sortibràn ANC, Andrade-Cetto A. Rodriguez-Arnaiz R 2008. Genotoxicity testing of Cecropia obtusifolia extracts in two in vivo assays: The wing somatic mutation and recombination test of drosophila and the human cytokinesis-block micronucleus test. J. Ethnopharmacol. 116, 58–63.
Üngeder Ü, Aydın SA, Basaran AA, Basaran N 2004. The modulating effects of quercetin and rutin on the mitomycin C induced DNA damage. Toxicol. Lett. 151, 143–149.
Wang TY, Lia Q, Bia KS 2018. Bioactive flavonoids in medicinal plants: Structure, Activity and Biological fate. Asian J. Pharm. Sci. 13, 12–23.
Waters MD, Brady AL, Stack HF, Broxkman HE 1990. Antimutagenic profiles for some model compounds. Mutat. Res. 238, 57–85.
Yousefipour Z, Ranganna K, Newaz MA, Milton SG 2005. Mechanism of acrolein-induced vascular toxicity. J. Physiol. Pharmacol. 56, 337–353.
Yu Q, Nie SP, Wang JQ, Liu XZ, Yin PF, Huang DF, Li WJ, Gong DM, Xie MY 2014. Chemoprotective effects of Ganoderma atrum polysaccharide in cyclophosphamide-induced mice. Int. J. Biol. Macromol. 64, 395–401.
Zang Y, Igarashi K, Li Y 2016. Anti-diabetic effects of luteolin and luteolin-7-O-glucoside on KK-Ay mice. Biosci. Biotechnol. Biochem. 80, 1580-1586.
Zhang L, Gong AG, Riaz K, Deng JY, Ho CM, Lin HQ, Dong TT, Lee YK, Tsim KW 2017. A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide-induced anemic rats. FEBS Open Bio 7, 318–323.
Zhou J, Qi Y, Ritho J, Zhang Y, Zheng X, Wu L, Li Y, Sun L 2016. Flavonoid glycosides as floral origin markers to discriminate of unifloral bee pollen by LC-MS/MS. J. Ethnopharmacol. 181, 20–25.
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2020-08-31
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LUIZ, Tatiane Cordeiro; RIALTO, Luiz Henrique; DE MOURA, Fernando Rafael; AGUIAR, Danilo Henrique; SUGUI, Marina Mariko; BICUDO, Rogério de Campos; SINHORIN, Adilson Paulo; SINHORIN, Valéria Dornelles Gindri. Chemoprotective Effect of Leaf Extracts of Cecropia distachya Huber (Urticaceae) in Mice Submitted to Oxidative Stress Induced by Cyclophosphamide. Fronteira: Journal of Social, Technological and Environmental Science, [S. l.], v. 9, n. 2, p. 103–127, 2020. DOI: 10.21664/2238-8869.2020v9i2.p103-127. Disponível em: https://revistas2.unievangelica.edu.br/index.php/fronteiras/article/view/3022. Acesso em: 23 nov. 2024.
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