Perfil de resistência bacteriana em pacientes atendidos no laboratório clínico da Pontifícia Universidade Católica de Goiás, no ano de 2014
DOI:
https://doi.org/10.29237/2358-9868.2019v7i2.p123-131Keywords:
Infecção do trato uninário, Resistência bacteriana, ITUAbstract
Objective: To profile antimicrobial resistance in patients with urinary tract infection and to evaluate the most common uropathogens found in patients treated at the PUC Goiás Clinical Laboratory. Methods: This is a retrospective study of the descriptive type of data collection of the Microbiology of the PUC Goiás Clinical Laboratory. Results: We analyzed 3250 urine cultures with antibiogram, with 405 (12.5%) positive and higher prevalence in patients aged 19-54 years with 215 (53.1%) cases. A total of 352 (86.9%) positive samples from female patients were identified, with E. coli 189 (53.7%) being the most prevalent pathogen within the female group. The prevalence of gram-negative bacteria was 305 (75.3%) of the cases, with a predominance of E. coli with 209 (51.6%) of the total cases. Other agents such as coagulase negative Staphylococcus 28 (6.9%) cases, Staphylococcus aureus 26 (6.4%) cases and Klebsiella pneumoniae 26 (6.4%) cases were also observed. Of all antimicrobials tested, the highest resistance found among the gram-negative group of bacteria was Ceftazidime (CAZ), being resistant to 59.3% of the tested samples. The highest resistance found within the group of gram-positive bacteria was Penicillin (PEN) in 63% of cases. Conclusion: It is concluded that UTI is the most frequent morbidity today, affecting anyone, most frequently in females and with prevalence of Escherichia coli, being the most isolated uropathogen.
References
2. VALIQUETTE L. Urinary tract infections in women. Canadian Journal of Urology 8: 6-12, 2001.
3. KARLOWSKY JA, LAGACÉ-WIENS PR, SIMNER PJ, et al. Antimicrobial resistance in urinary tract pathogens in Canada from 2007 to 2009: CANWARD surveillance study. Antimicrob Agents Chemother. 2011;55(7):3169–3175. doi:10.1128/AAC.00066-11
4. ORTIZ V, MAIA RS. Como Diagnosticar e Tratar Infecções do trato urinário. Revista Brasileira de Medicina 56:149-155, 1999
5. GUPTAK, HOOTON TM, ROBERTS PL, ET AL. Patient-initiated treatment of uncomplicated recurrent urinary tract infections in Young women. Ann Intern Med. 135(1): 9-16, 2001.
6. HAZELETT SE, TSAI M, GARERI M, ALLEN K. The association between indwelling urinary catheter use in the elderly and urinary tract infection in acute care. BMC Geriatr. 2006; 6:15.
7. LUCCHETTI G, SILVA AJ, UEDA SMY, PEREZ MCD, MIMICA LMJ. Infecções do trato urinário: análise da frequência e do perfil de sensibilidade dos agentes causadores de infecções do trato urinário em pacientes com cateterização vesical crônica. J. Bras. Patol. Med. Lab. [online]. 2005, vol.41, n.6 [cited 2019-10-26], pp.383-389.
8. DEL FIOL FS, LOPES LC, TOLEDO MI, BARBERATO-FILHO S. Perfil de prescrições e uso de antibióticos em infecções comunitárias. Rev. Soc. Bras. Med. Trop. [Internet]. 2010 Feb [cited 2019 Oct 26]; 43(1): 68-72.
9. SANTOS, NQ. A resistência bacteriana no contexto da infecção hospitalar. Texto contexto - enferm. [online]. 2004, vol.13, n.spe [cited 2019-10-26], pp.64-70.
10. HEILBERG, I. P., SCHOR, N. Abordagem diagnóstica e terapêutica na infecção do trato urinário-ITU. Ver. Assoc. Med. Bras, SP., 49(1): 109-116. 2003.
11. DIAS NETO JA, SILVA LDM, MARTINS ACP, TIRABOSCHI RB, DOMINGOS ALA, SUAID HJ et al. Prevalence and bacterial susceptibility of hospital acquired urinary tract infection. Acta Cir. Bras. [online]. 2003, vol.18, suppl.5 [cited 2019-10-26], pp.36-38.
12. WILSON M, GAIDO L. Laboratory diagnosis of urinary tract infections in adult patients. Med. Microbiol, 38: 1150-8, 2004.
13. CAMARGO C, PEDRO C, LOURENÇO D, GIRONI RH, MARTINEZ R. Infecção de vias urinarias na com unidade de ribeirão preto - sp: etiologia, sensibilidade bacteriana a antimicrobianos e implicações terapêuticas. Medicina (Ribeirão Preto, Online) [Internet]. 30jun.2002 [citado 26out.2019];35(2):173-8.
14. CAMARGO I, MASCHIETO A, SALVINO C, DARINI AL. Diagnóstico bacteriológico das infecções do trato urinário - uma revisão técnica. Medicina (Ribeirão Preto, Online) [Internet]. 30mar.2001 [citado 26out.2019];34(1):70-8.
15. SÁEZ-LIORENS X, CASTREJÓN-DE WONG M, CATAÑO E, DE SUMAN O, MORÓS DA. Impact of an antibiotic restriction policy on hospital expenditures and bacterial susceptibilities: a lesson from a pediatric institution in a developing country. Pediatric Infect Dis J., 19(3):200-6, 2000.
16. KADOSAKI LL, DE SOUSA SF, BORGES JCM. Analysis of use and bacterial resistance to antimicrobial in level hospital. Rev. Bras. Farm. 93(2): 128-135, 2012.
17. ANDRADE S, SADER H, JONES R, PEREIRA A, PIGNATARARI A, GALES A. Increased resistance to first-line agents among bacterial pathogens isolated from urinary tract infections in Latin America: time for local guidelines? Mem Inst Oswaldo Cruz, 101(7): 741-8, 2006.
18. FOXMAN B. The epidemiology of urinary tract infection. Nat Rev Urol. 2010 Dec;7(12):653-60.
19. RODRIGUES FJB, BARROSO APD. Etiologia e sensibilidade bacteriana em infecções do trato urinário. Ver Port Saúde Pública, 29 (2): 123-31, 2011.
20. AL-MARDENI RI, BATARSEH A, OMAISH L, ET AL. Empirical treatment for pediatric urinary tract infection and resistance patterns of uropathogend, in Queen Alia hospital and Prince A’Isha military Center-Jordan. Saudi J Kidney Dis Transpl. 20(1):135-9, 2009.
21. OLIVEIRA FA, NOGUEIRA KS. Resistência a fluoroquilomonas em Escherichia coli isoladas em cultura de urina. Ver Bras Anal Clín., 43(2);152-4, 2011.
22. NYS S, VAN MERODE T, BARTELDS AI, ET AL. Urinary tract infection in general practice patients: diagnostic tests versus bacteriological culture. J Antimicrob Chermother, 57(5); 955-8, 2006.
23. MARQUES ML, CHADE DC, DOURADO FL. Aumento da resistência bacteriana no controle de infecção urinária adquirida na comunidade. Sinopse de urologia, 9(5): 121-122, 2005.
